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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015-02-18 - 2015-02-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
ca. 2.96
Temp.:
22.4 °C
Remarks on result:
not measured/tested
Remarks:
pH

Table: Retention Times, Capacity Factors and Partition Coefficients

       Test Item

 tR [min]

 k

 log k

    log Pow

6.814 

13.1

 1.12

 1st Calibration

 2nd Calibration

6.813 

 13.1

 1.12

2.96 +/- 0.09

2.72 to 3.21 (95 % CI) 

2.96 +/- 0.09

2.73 to 3.20 (95 % CI)

 Mean value

 6.814

 13.1

1.12

    2.96

tR : Retention time

k: Capacity factor test item

Pow: Partition Coefficient (n-octanol / water)

CI: Confidence Interval

Temperature:

The mean temperature of 22.4 °C was inside the ranges of 20 -25°C ± 1°C during the course of the study.

The signal to noise ratio was > 3

The HPLC void time (to) was determined by threefold injection of a solution of 5 mg/L NaNO3.

Serial no.

To [min]

1

0.481

2

0.482

3

0.484

MEAN

0.482

 

Regression Line: The correlation coefficient r for both calibartions was >0.9

 

1st calibration

2ndcalibration

Slope

2.336

2.333

Y-intercept

0.3474

0.3508

0.9747

0.9757

r

0.9873

0.9878

Conclusions:
A log Pow of 2.96 was determined for the test item.
Executive summary:

The test item has a partition coefficient log Pow of 2.96 at 22.4 °C as determined by HPLC method according to EU Method A.8, and OECD Test Guideline 117 (2004)

Description of key information

log Pow = 2.96

Key value for chemical safety assessment

Log Kow (Log Pow):
2.96
at the temperature of:
22.4 °C

Additional information

The test item has a partition coefficient log Pow of 2.96 at 22.4 °C as determined by HPLC method according to EU Method A.8, and OECD Test Guideline 117 (2004)