Registration Dossier
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EC number: 206-137-4 | CAS number: 303-26-4
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity to aquatic invertebrate was predicted 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4). EC50 intoxication value was estimated to be 116.794 mg/l for Daphnia magna for 48 hrs duration. It was concluded that 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4) was likely to be not toxic to aquatic invertebrate.
Toxicity to aquatic algae and cyanobacteria
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity to aquatic algae was predicted 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4). EC50 growth rate value was estimated to be 112.764 mg/l for Pseudokirchneriella subcapitata for 72 hrs duration. It was concluded that 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4) was likely to be not toxic to aquatic algae.
Additional information
Short-term toxicity to aquatic invertebrates
Following three studies of target chemical and structurally similar read across includes predicted data and experimental data to conclude the toxicity extent of 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4) towards aquatic invertebrate is summarized as follows:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity to aquatic invertebrate was predicted 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4). EC50 intoxication value was estimated to be 116.794 mg/l for Daphnia magna for 48 hrs duration. It was concluded that 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4) was likely to be not toxic to aquatic invertebrate.
The above predicted data of target chemical is supported by the experimental study of structurally similar read across disodium 2-dibutylaminoethanol (CAS: 102 -81 -8) from the J-CHeck, suggests that theShort term toxicity test was carried out acoording to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) to study the effects on aquatic environment. mobility was measured during the test. The effective concentration to 50% of Daphnia magna when exposed to 2-dibutylaminoethanol for 48 hr is >110 mg/L. It can be concluded from the value that 2-dibutylaminoethanol (CAS: 102 -81 -8) is not toxic/toxic to the aquatic invertebrate and can be considered as “not classified” as per the classification criteria for aquatic environment.
Another supporting experimental study for the structurally similar read across piperazine (CAS: 110-85-0) from the J-CHeck 2017, also suggests that theShort term toxicity to aquatic invertebrates was performed according to the OECD guideline 202.The test was conducted for 48 hrs and EC 50 value was observed.
After experiment the EC50 value for short term toxicity to aquatic invertebrates for piperazine (CAS: 110-85-0) was determined to be 110 mg/l.
On the basis of results for toxicity to aquatic invertebrates, it can be considered that the substance is not likely to be toxic to aquatic invertebrates and can be considered as not classified as per the CLP regulation.
Thus based on the effect concentrations which is in the range 110 mg/l to 116.794 mg/l give the conclusion that test substance 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4) was likely to be not toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered to be “not classified” as per the CLP classification criteria.
Toxicity to aquatic algae and cyanobacteria
Following studies of target chemical and structurally similar read across includes predicted data and experimental data to conclude the toxicity extent of 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4) towards aquatic invertebrate is summarized as follows:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity to aquatic algae was predicted 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4). EC50 growth rate value was estimated to be 112.764 mg/l for Pseudokirchneriella subcapitata for 72 hrs duration. It was concluded that 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4) was likely to be not toxic to aquatic algae.
The above predicted data of target chemical is supported by the experimental study of structurally similar read across disodium 2-dibutylaminoethanol (CAS: 102 -81 -8) from the J-CHeck, suggests that theShort term toxicity test was carried out acoording to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) to study the effects on aquatic environment. mobility was measured during the test. The effective concentration to 50% of Daphnia magna when exposed to 2-dibutylaminoethanol for 48 hr is >110 mg/L. It can be concluded from the value that 2-dibutylaminoethanol (CAS: 102 -81 -8) is not toxic/toxic to the aquatic invertebrate and can be considered as “not classified” as per the classification criteria for aquatic environment.
Another supporting experimental study for the structurally similar read across piperazine (CAS: 110-85-0) from the J-CHeck 2017, also suggests that theShort term toxicity to aquatic invertebrates was performed according to the OECD guideline 202.The test was conducted for 48 hrs and EC 50 value was observed.
After experiment the EC50 value for short term toxicity to aquatic invertebrates for piperazine (CAS: 110-85-0) was determined to be 110 mg/l.
On the basis of results for toxicity to aquatic invertebrates, it can be considered that the substance is not likely to be toxic to aquatic invertebrates and can be considered as not classified as per the CLP regulation.
Thus based on the effect concentrations which is in the range 110 mg/l to 112.764 mg/l give the conclusion that test substance 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS: 303-26-4) was likely to be not toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered to be “not classified” as per the CLP classification criteria.
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