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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
not specified
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract
Remarks:
Publication in Russian

Data source

Reference
Reference Type:
publication
Title:
1,3-DFB: No information
Author:
No information
Year:
1965
Bibliographic source:
Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. Vol. 3, Pg. 91

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-difluorobenzene
EC Number:
206-746-5
EC Name:
1,3-difluorobenzene
Cas Number:
372-18-9
Molecular formula:
C6H4F2
IUPAC Name:
1,3-difluorobenzene
Test material form:
liquid
Details on test material:
Name of the test material: 1,3-difluorobenzene
No data available

Test animals

Species:
mouse

Administration / exposure

Route of administration:
inhalation
Duration of exposure:
2 h

Results and discussion

Effect levelsopen allclose all
Dose descriptor:
LC50
Effect level:
55 mg/L air
Exp. duration:
2 h
Dose descriptor:
LC50
Effect level:
43.65 mg/L air
Exp. duration:
4 h
Remarks on result:
other: calculated with Haber's law
Clinical signs:
other: Brain and coverings: recordings from specific areas of central nervous system

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute inhalation LC50 - 2h value of 1,3-difluorobenzene was found to be 55 mg/L in mouse. The LC50 - 4h calculated with Haber's law was found to be 43.65 mg/L.

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