Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-988-4 | CAS number: 504-29-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Remarks:
- No further details.
- Details on sampling:
- The concentration of the test substance in the test solution was measured at the beginning and the end of exposure, and the average value was between 95% and 100% of the set concentration.
- Vehicle:
- not specified
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Nominal and measured concentrations:
- Not specified.
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 12 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the growth rate, the 72h-EC50 of the test item in algae is 12 mg/L and the 72h-NOEC is 2.1 mg/L.
- Executive summary:
A growth inhibition test was conducted with the test item in Psedokirchneriella subcapitata, according to the OECD guideline 201, under GLP conditions. The test item concentration was measured at the beginning and at the end of the exposure time, and remained within 95 -100% of the nominal value. Based on the growth rate, the 72h-EC50 of the test item in algae was found to be 12 mg/L and the 72h-NOEC was 2.1 mg/L (average value of the measured concentration).
Reference
Description of key information
Key study. Method according to OECD 201, GLP study. The 72h-EC50 of the test item in algae is 12 mg/L, and the 72h-NOEC is 2.1 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 12 mg/L
- EC10 or NOEC for freshwater algae:
- 2.1 mg/L
Additional information
A growth inhibition test was conducted with the test item inPsedokirchneriella subcapitata, according to the OECD guideline 201, under GLP conditions. The test item concentration was measured at the beginning and at the end of the exposure time, and remained within 95 -100% of the nominal value. Based on the growth rate, the 72h-EC50 of the test item in algae was found to be 12 mg/L and the 72h-NOEC was 2.1 mg/L (average value of the measured concentration).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
