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Administrative data

Description of key information

Acute oral toxicity. Weight of evidence. Based on the available information (peer reviewed handbook data), the oral LD50 in rats is 200 mg/kg bw.

Acute inhalation toxicity. No study available. Supporting data: According to handbook data, a tolerance of 0.5 ppm in humans has been reported.

Acute dermal toxicity. Supporting study. The LD50 of the test item in guinea pigs is 500 mg/kg bw, according to peer reviewed handbook data.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline available
Principles of method if other than guideline:
Data from peer reviewed handbook. No data provided on methods.
GLP compliance:
not specified
Test type:
other: not specified.
Specific details on test material used for the study:
- pyridin-2-amine / 504-29-0 / 207-988-4
- State: powder
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
200 mg/kg bw
Based on:
test mat.
Interpretation of results:
Category 3 based on GHS criteria
Remarks:
EU criteria
Conclusions:
According to handbook data, the oral DL50 for rat is 200 mg/kg bw.
Executive summary:

According to 'Sax's Dangerous Properties of Industrial Materials', 11th edition, 'Kirk-Othmer Encyclopedia of Chemical Technology', and Patty’s Toxicology, 6th Edition, (peer reviewed handbook data), the oral DL50 for rat is 200 mg/kg bw.

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline available
Principles of method if other than guideline:
Data from peer reviewed handbook. No data provided on methods.
GLP compliance:
not specified
Test type:
other: not specified.
Specific details on test material used for the study:
pyridin-2-amine
Species:
other: human
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Key result
Sex:
not specified
Dose descriptor:
other: TCLo
Effect level:
0.5 other: ppm
Based on:
test mat.
Interpretation of results:
Category 3 based on GHS criteria
Remarks:
EU criteria.
Conclusions:
According to handbook data, the test item is highly toxic by ingestion and inhalation. Tolerance: 0.5ppm.
Executive summary:

According to 'The condensed chemical dictionary', 8th edition (peer reviewed handbook data), the test item is highly toxic by ingestion and inhalation. Tolerance: 0.5 ppm.

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline available
Principles of method if other than guideline:
Data from peer reviewed handbook. No data provided on methods.
GLP compliance:
not specified
Test type:
other: not specified.
Limit test:
no
Species:
other: quail
Strain:
other: Coturnix coturnix
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: wild
- Fasting period before study: no
- Housing: individually caged
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 2-6 weeks.
Route of administration:
oral: gavage
Vehicle:
propylene glycol
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 175 µL
Doses:
Not specified.
No. of animals per sex per dose:
4-6 animals per dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Observations: Data recorded included affectation time, induction and duration of immobilization, mortality, regurgitation, weight gain or loss, and any unique pliysiological effects.
- Frequency of observations and weighing: daily observations.
- Necropsy of survivors performed: no
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
133 mg/kg bw
Based on:
test mat.
Interpretation of results:
Category 3 based on GHS criteria
Remarks:
EU criteria.
Conclusions:
According to handbook data, the oral LD50 for quail is 133 mg/kg bw.
Executive summary:

According to 'The dictionary of substance and their effects', and 'Sax's Dangerous Properties of Indutrial Materials', 11th edition (peer reviewed handbook data), based on an acute oral toxicity study on quail (Coturnix coturnix), the oral LD50 for quail is 133 mg/kg bw.

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline available
Principles of method if other than guideline:
No data on methods.
GLP compliance:
not specified
Remarks:
data from handbook, no further information provided.
Test type:
other: not specified.
Limit test:
no
Specific details on test material used for the study:
2-aminopyridine
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
50 mg/kg bw
Based on:
test mat.
Interpretation of results:
Category 3 based on GHS criteria
Remarks:
EU criteria.
Conclusions:
According to handbook data, the oral LD50 for mice is 50 mg/kg bw.
Executive summary:

According to 'Patty’s Toxicology', 6th edition (peer reviewed handbook data), the oral LD50 for mice is 50 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
200 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Data from peer reviewed handbook. No data provided on methods.
GLP compliance:
not specified
Test type:
other: not specified.
Species:
guinea pig
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 500 mg/kg bw
Based on:
test mat.
Interpretation of results:
Category 3 based on GHS criteria
Remarks:
EU criteria.
Conclusions:
The LD50 of the test item is ca. 500 mg/kg.
Executive summary:

As reported in 'Patty's Toxicology', 6th edition (peer reviewed handbook data), dermal absorption in guinea pigs occurs readily for the test item, as indicated by an approximate LD50 of 500 mg/kg; deaths were accompanied by convulsions.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 000 mg/kg bw

Additional information

Acute Oral Toxicity: According to 'Sax's Dangerous Properties of Industrial Materials', 11th edition, 'Kirk-Othmer Encyclopedia of Chemical Technology', and Patty’s Toxicology, 6th Edition, (peer reviewed handbook data), the oral LD50 for rat is 200 mg/kg bw. According to 'The condensed chemical dictionary', 8th edition (peer reviewed handbook data), the test item is highly toxic by ingestion and inhalation. Tolerance: 0.5ppm. According to 'The dictionary of substance and their effects', and 'Sax's Dangerous Properties of Indutrial Materials', 11th edition (peer reviewed handbook data), based on an acute oral toxicity study of the test item on quail (Coturnix coturnix), the oral LD50 for quail is 133 mg/kg bw. According to 'Patty’s Toxicology', 6th edition (peer reviewed handbook data), the oral LD50 for mice is 50 mg/kg bw. As the preferred species for acute oral toxicity studies is the rat, the key value is considered to be 200 mg/kg bw, based on the available information.

Acute Inhalatory Toxicity: No study was available. Supporting data: According to handbook data, a tolerance of 0.5 ppm in humans has been reported.

Acute Dermal Toxicity: Supporting study: According to 'Patty's Toxicology', 6th ed., dermal absorption in guinea pigs occurs readily for the test item, as indicated by an approximate LD50 of 500 mg/kg; deaths were accompanied by convulsions.

Acute toxicity, other routes: According to peer reviewed handbook data, the LC50 of the test item in mice is 35 mg/kg bw by intraperitoneal route, 70 mg/kg bw by intravenous route, and 23 mg/kg bw by intravenous route.

Justification for classification or non-classification

Based on the available information (oral LC50 between 50 and 300 mg/kg bw), the test item is classified as Acute Oral Category 3, H301, according to CLP Regulation (EC) No. 1272/2008.

Based on the available information (dermal LC50 between 200 and 1000 mg/kg bw), the test item is classified as Acute Dermal Category 3, H311, according to CLP Regulation (EC) No. 1272/2008.