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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004
Reference Type:
publication
Title:
Unnamed
Year:
2005
Report date:
2005
Reference Type:
publication
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Data from peer reviewed handbook. No data provided on methods.
GLP compliance:
not specified
Test type:
other: not specified.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-pyridylamine
EC Number:
207-988-4
EC Name:
2-pyridylamine
Cas Number:
504-29-0
Molecular formula:
C5H6N2
IUPAC Name:
pyridin-2-amine
Specific details on test material used for the study:
- pyridin-2-amine / 504-29-0 / 207-988-4
- State: powder

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
200 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Remarks:
EU criteria
Conclusions:
According to handbook data, the oral DL50 for rat is 200 mg/kg bw.
Executive summary:

According to 'Sax's Dangerous Properties of Industrial Materials', 11th edition, 'Kirk-Othmer Encyclopedia of Chemical Technology', and Patty’s Toxicology, 6th Edition, (peer reviewed handbook data), the oral DL50 for rat is 200 mg/kg bw.

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