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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004
Reference Type:
publication
Title:
Unnamed
Year:
2005
Report date:
2005
Reference Type:
publication
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Data from peer reviewed handbook. No data provided on methods.
GLP compliance:
not specified
Test type:
other: not specified.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-pyridylamine
EC Number:
207-988-4
EC Name:
2-pyridylamine
Cas Number:
504-29-0
Molecular formula:
C5H6N2
IUPAC Name:
pyridin-2-amine
Specific details on test material used for the study:
- pyridin-2-amine / 504-29-0 / 207-988-4
- State: powder

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
200 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Remarks:
EU criteria
Conclusions:
According to handbook data, the oral DL50 for rat is 200 mg/kg bw.
Executive summary:

According to 'Sax's Dangerous Properties of Industrial Materials', 11th edition, 'Kirk-Othmer Encyclopedia of Chemical Technology', and Patty’s Toxicology, 6th Edition, (peer reviewed handbook data), the oral DL50 for rat is 200 mg/kg bw.