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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Principles of method if other than guideline:
Data from peer reviewed handbook. No data provided on methods.
GLP compliance:
not specified
Test type:
other: not specified.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-pyridylamine
EC Number:
207-988-4
EC Name:
2-pyridylamine
Cas Number:
504-29-0
Molecular formula:
C5H6N2
IUPAC Name:
pyridin-2-amine

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 500 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Remarks:
EU criteria.
Conclusions:
The LD50 of the test item is ca. 500 mg/kg.
Executive summary:

As reported in 'Patty's Toxicology', 6th edition (peer reviewed handbook data), dermal absorption in guinea pigs occurs readily for the test item, as indicated by an approximate LD50 of 500 mg/kg; deaths were accompanied by convulsions.

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