Registration Dossier
Registration Dossier
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EC number: 207-988-4 | CAS number: 504-29-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Principles of method if other than guideline:
- Data from peer reviewed handbook. No data provided on methods.
- GLP compliance:
- not specified
- Test type:
- other: not specified.
Test material
- Reference substance name:
- 2-pyridylamine
- EC Number:
- 207-988-4
- EC Name:
- 2-pyridylamine
- Cas Number:
- 504-29-0
- Molecular formula:
- C5H6N2
- IUPAC Name:
- pyridin-2-amine
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 500 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- EU criteria.
- Conclusions:
- The LD50 of the test item is ca. 500 mg/kg.
- Executive summary:
As reported in 'Patty's Toxicology', 6th edition (peer reviewed handbook data), dermal absorption in guinea pigs occurs readily for the test item, as indicated by an approximate LD50 of 500 mg/kg; deaths were accompanied by convulsions.
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