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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Bioalkylation and biooxidation of anthracene, in vitro and in vivo.
Author:
Myers SR, Blake JW, Flesher JW
Year:
1988
Bibliographic source:
Biochem. Biophys. Res. Comm. 151, 1441-1445

Materials and methods

Objective of study:
metabolism
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity: no impurities detected (HPLC, GC/MS)
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
subcutaneous

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes

Any other information on results incl. tables

Anthracene is metabolized in vivo (Sprague-Dawley rats, m;
subcutaneous tissue) and in vitro (rat liver cytosol
preparations) to 9-methyl and 9,10-dimethylanthracene. 

These compounds are further decomposed to
9-hydroxymethylanthracene and
9-hydroxymethyl-10-methylanthracene as well as
9-formylanthracene and dihydroxymethylanthracene.

Applicant's summary and conclusion