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Toxicological information

Carcinogenicity

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Description of key information

Ziram is not carcinogenic in mice or rats

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Dose descriptor:
NOAEL
34.6 mg/kg bw/day

Additional information

At 24 mg/kg bw/d, male rats showed treatment-related haemangiomata in mesenteric lymph nodes and spleen. These haemangiomata were not pronounced, did not show evidence of malignancy and were confined to this group and sex only.

In mice, ziram did not induce tumours at dose levels up to 82 mg/kg bw for 80 weeks. In all treated groups, increased incidences of centrilobular and/or generalised hepatocellular enlargement were seen. Urinary bladder epithelial hyperplasia was observed in males and females receiving 82 mg/kg bw and in males receiving 27 mg/kg bw.

The NOAEL was lower than 3 mg/kg bw/d. Pulmonary tumours, found in one study, occurred in the presence of a virus


Carcinogenicity: via oral route (target organ): cardiovascular / hematological: other

Justification for classification or non-classification

No treatment-related and toxicologically significant tumours were detected in rats or mice.