Registration Dossier
Registration Dossier
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EC number: 812-121-3 | CAS number: 169280-06-2
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-(4-cyclopropanecarbonylphenyl)-2-methylpropanenitrile
- EC Number:
- 812-121-3
- Cas Number:
- 169280-06-2
- Molecular formula:
- C14 H15 N O
- IUPAC Name:
- 2-(4-cyclopropanecarbonylphenyl)-2-methylpropanenitrile
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Duration of test (contact time):
- <= 28 d
Initial test substance concentration
- Initial conc.:
- <= 102.5 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The test item p-CPK-Nitrile was investigated for its ready biodegradability in a manometric respirometry test over a period of 28 days. The biodegradation was followed by the oxygen uptake of the microorganisms during exposure. As a reference item sodium benzoate was tested simultaneously under the same conditions as the test item, and functioned as a procedure control.
Test conditions: 22°C, darkness, climatised chamber, pH of 7.6-7.7 (test start) and 7.6-8.3 (test end)
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 0
- Sampling time:
- 28 d
- Details on results:
- The degradation rate of p-CPK-Nitrile was 0% after 28 days (ThOD(NH4), ThOD(NO3)). Therefore, the substance is considered to be not readily biodegradable.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Based on the experimental results, p-CPK-Nitrile is considered to be not readily biodegradable.
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