Registration Dossier
Registration Dossier
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EC number: 208-914-3 | CAS number: 546-89-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The Comparative Toxicity of certain Lithium compounds in acute experiments on animals
- Author:
- Neretin, V.
- Year:
- 1 958
- Bibliographic source:
- Farmakol Toksikol. 1958 Jul-Aug;21(4):93-5.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Parameters analysed / observed: The minimum lethal dose was investigated. The toxicity of the test substance was determined according to the survival of the animals and their general conditions. The animals were observed for 30 days after the administration of the solution.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Lithium acetate
- EC Number:
- 208-914-3
- EC Name:
- Lithium acetate
- Cas Number:
- 546-89-4
- Molecular formula:
- LiCH3CO2 (not C2H4O2.Li)
- IUPAC Name:
- lithium acetate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 21 - 23 g
- Acclimation period: 10 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1 mL
- No. of animals per sex per dose:
- 20
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 1 500 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- Animals that died revealed morphological changes of the lungs, brain and liver that were characterised as sharply expressed polyemia. Selective degeneration mainly affected liver, kidney and the nervous system. Morphological changes increased with the dosage of the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- According to Neretin et al. an LDLo of 1500 mg/kg bw was determined for mice.
- Executive summary:
Lithium acetate was tested on 20 white mice per dose group in an acute toxicity study (Neretin, 1958). The LDLo- and LD100-levels in this study were 1500 mg/kg bw and 4000 mg/kg bw, respectively.
Animals that died revealed morphological changes of the lungs, brain and liver that were characterised as sharply expressed polyemia. Selective degeneration mainly affected liver, kidney and the nervous system. Morphological changes increased with the dosage of the test substance.
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