Registration Dossier
Registration Dossier
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EC number: 274-366-7 | CAS number: 70179-77-0
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD107
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Sodium 3-[[4-amino-9,10-dihydro-3-[2-(2-methoxyethoxy)ethoxy]-9,10-dioxo-1-anthryl]amino]-2,4,6-trimethylbenzenesulphonate
- EC Number:
- 274-366-7
- EC Name:
- Sodium 3-[[4-amino-9,10-dihydro-3-[2-(2-methoxyethoxy)ethoxy]-9,10-dioxo-1-anthryl]amino]-2,4,6-trimethylbenzenesulphonate
- Cas Number:
- 70179-77-0
- Molecular formula:
- C28H30N2O8S.Na
- IUPAC Name:
- sodium 3-[[4-amino-9,10-dihydro-3-[2-(2-methoxyethoxy)ethoxy]-9,10-dioxo-1-anthryl]amino]-2,4,6-trimethylbenzenesulphonate
- Test material form:
- solid: bulk
Constituent 1
Study design
- Analytical method:
- liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -0.27
- Temp.:
- 23 °C
- pH:
- ca. 8.4
- Details on results:
- A saturated stock solution of the test substance in water saturated n-octanol was prepared.
To 5 ml, 10 ml and 20 ml of the stock solution 10 ml of n-octanol saturated water were added. The two-phase system was shaken vigorously at room temperature (23 °C) for one hour. Subsequently the phases were separated by centrifugation for 15 mion at 5000 rpm. The test substance concentration in each phase was determined by HPLC.
Stock solution: 1244 mg/l = 843 mg/l active substance.
Applicant's summary and conclusion
- Conclusions:
- The test substance has a log Pow of -0.27 at 23°C.
- Executive summary:
The log Pow of the test substance was determined according OECD107. The log Pow at 23 °C is -0.27.
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