Registration Dossier
Registration Dossier
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Reaction products of diazotised 2-amin-6-nitrophenol-4-sulphonic Acid and 2-Amino-4-nitrophenol-6-sulfonic Acid, coupled with a mixture of 6-Amino-4-hydroxy-2-naphthalenesulfonic Acid and Acetylated 6-Amino-4-hydroxy-2-naphthalenesulfonic Acid, subsequently metallized with Chromium (III) Basic Sulfate and Acetic Acid, and at the end diazotised and coupled with p-Cresol, sodium salts
EC number: 405-750-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
not skin sensitiser
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In the CLP Regulation (EC 1272/2008), in the section 3.4 Respiratory or skin sensitisation, a skin sensitizer is defined as a substance that will lead to an allergic response following skin contact.
A substance shall be classified as skin sensitisers (Category 1) where data are not sufficient for sub-categorisation (1A and 1B) in accordance with the following criteria:
(a) if there is evidence in humans that the substance can lead to sensitisation by skin contact in a substantial number of persons; or
(b) if there are positive results from an appropriate animal test (according to 3.4.2.2.4.1).
If, in order to evaluate skin sensitisation potential, a Guinea pig maximisation test is performed, a substance is classified as skin sensitiser when the response of at least 30 % responding at ≤ 0,1 % intradermal induction dose or at least 60 % responding at > 0,1 % to ≤ 1 % intradermal induction dose.
Under the test conditions the substance resulted in a sensitisation rate of 0 % after intra-cutaneous and epi-cutaneous application to the guinea pig. Therefore, according to the CLP Regulation (EC 1272/2008), the substance is not classified as skin sensitiser.
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