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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-745-3 | CAS number: 71-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
According to Guidance document Chapter R.7b, section R.7.8 short-term toxicity tests to fish do not need to be conducted if there are mitigating factors indicating that aquatic toxicity is unlikely to occur.
Nevertheless, the short-term toxicity to fish was calculated by EpiSuite's EcoSAR model. ECOSAR estimates the 96h LC50 for fish to be 375000 mg/L. This is far above water solubility so mortalities greater than 50% would not occur in a saturated solution during an exposure period of 96 hours.
Key value for chemical safety assessment
Additional information
According to Guidance document Chapter R.7b, section R.7.8 short-term toxicity tests to fish do not need to be conducted if there are mitigating factors indicating that aquatic toxicity is unlikely to occur.
Nevertheless, the short-term toxicity to fish was calculated by EpiSuite's EcoSAR model.
The suitability of the model was assessed and it was concluded that L-histidine is considered to be inside the applicability domain of the EpiSuite EcoSAR model.
ECOSAR estimates the 96h LC50 for fish to be 375000 mg/L.
This estimated LC50 value (375 g/L) exceeds the water solubility of L-histidine (43 g/L), therefore, it can be expected that mortalities greater than 50% would not occur in a saturated solution during an exposure period of 96 hours.
The QSAR results indicated that there is a very low toxicity to fish, and that the algae and invertebrates are more sensitive. For this reason, tests have been performed to investigate the toxicity towards algae and invertebrates. Taken together with the fact that in this way we can diminish the use of test animals by the use of alternative testing, which is one of the pillars of the REACH regulation, a short-term toxicity test for fish is not needed for L-histidine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.