Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-745-3 | CAS number: 71-00-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
According to Guidance document Chapter R.7b, section R.7.8 short-term toxicity tests to fish do not need to be conducted if there are mitigating factors indicating that aquatic toxicity is unlikely to occur.
Nevertheless, the short-term toxicity to fish was calculated by EpiSuite's EcoSAR model. ECOSAR estimates the 96h LC50 for fish to be 375000 mg/L. This is far above water solubility so mortalities greater than 50% would not occur in a saturated solution during an exposure period of 96 hours.
Key value for chemical safety assessment
Additional information
According to Guidance document Chapter R.7b, section R.7.8 short-term toxicity tests to fish do not need to be conducted if there are mitigating factors indicating that aquatic toxicity is unlikely to occur.
Nevertheless, the short-term toxicity to fish was calculated by EpiSuite's EcoSAR model.
The suitability of the model was assessed and it was concluded that L-histidine is considered to be inside the applicability domain of the EpiSuite EcoSAR model.
ECOSAR estimates the 96h LC50 for fish to be 375000 mg/L.
This estimated LC50 value (375 g/L) exceeds the water solubility of L-histidine (43 g/L), therefore, it can be expected that mortalities greater than 50% would not occur in a saturated solution during an exposure period of 96 hours.
The QSAR results indicated that there is a very low toxicity to fish, and that the algae and invertebrates are more sensitive. For this reason, tests have been performed to investigate the toxicity towards algae and invertebrates. Taken together with the fact that in this way we can diminish the use of test animals by the use of alternative testing, which is one of the pillars of the REACH regulation, a short-term toxicity test for fish is not needed for L-histidine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
