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EC number: 201-155-9
CAS number: 78-90-0
Penetration of rabbit skin was estimated by a technique closely to the
one-day cuff method of Draize and associates, using groups of four male
albino rabbits weighing 2.5 to 3.5 kg. The fur was removed from the
entire trunk by clipping, and the dose was retained beneath an
impervious plastic film. The animals were immobilized during the 24 hour
contact period, after which the film was removed and the rabbits were
caged for the subsequent 14 day observation period. No data regarding
mortality, clinical signs and body weight changes are given. The
reported LD50 for the penetration of rabbit skin is 0.5 ml/kg bw.
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