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EC number: 203-120-3 | CAS number: 103-53-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Toxic properties after a single oral dose of the test substance were investigated by observation for a period of 15 days.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Phenethyl cinnamate
- EC Number:
- 203-120-3
- EC Name:
- Phenethyl cinnamate
- Cas Number:
- 103-53-7
- Molecular formula:
- C17H16O2
- IUPAC Name:
- phenethyl cinnamate
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sunflower-seed oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20-45%
- Amount of vehicle (if gavage):0.2-0.5 mL/kg bw
- Justification for choice of vehicle: because of low solubility of the substance - Doses:
- 0.2 to 0.5 mL/kg bw of 20-45% solution in the vehicle
- No. of animals per sex per dose:
- 6 animals/sex/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 500 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- The test substance has a LD50 of 4500 mg/kg bw given as a single dose.
- Executive summary:
The study has been performed in order to investigate the toxic propreties of the test substance.
Each groups of 6 males and 6 females of guinea pigs were fed through a stomach tube perorally in the form of a 20 -45% solution in sunflower-seed oil (0.2 - 0.5 mL per kg bw) given as a single dose.
The animals were observed for 15 days.
No differences in the sex sensitivity of these animals were observed.
As a result, the test substance can be referred to as a low-toxic compound with an LD50 of 4500 mg/kg bw.
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