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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
EU Method A.6 (Water Solubility)
Version / remarks:
Cited as Directive 92/69/EEC, A.6
GLP compliance:
Type of method:
flask method
Water solubility:
0.53 - 0.64 g/L
20 °C
5 - 9
Water Solubility (g/liter):
1. In water at 10/20/30 degree C: 0.51/0.62/0.80 g/L;
2. In buffer pH 5 at 10/20/30 degree C: 0.43/0.53/0.70 g/L;
3. In buffer pH 7 at 10/20/30 degree C: 0.45/0.56/0.73 g/L;
4. In buffer pH 9 at 10/20/30 degree C: 0.52/0.64/0.84 g/L.
Interpretation of results: moderately soluble (100-1000 mg/L)

Description of key information

Water solubility: 0.53 - 0.64 g/L at pH = 5 – 9 (20 °C)

Key value for chemical safety assessment

Water solubility:
0.56 mg/L
at the temperature of:
20 °C

Additional information

Water solubility values of 0.53 (pH = 5, 20 °C), 0.56 (pH = 7, 20 °C) and 0.64 (pH = 9, 20 °C) were determined by the flask method according to EU Method A.6.