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Administrative data

Description of key information

not sensitising (OECD429/EU B.42, GLP, read-across from structural analogue)

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substance have similar skin sensitising properties because they share structural similarities with common functional groups. Source as well as target substance are both alkyltriphenylphosphonium halogen salts. The alkyltriphenylphosphonium moiety of source and target is almost identical, differing only in the length of the saturated linear alkyl chain (ethyl instead of n-butyl). The counterion is identical - bromide.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)

Source Target
Name Ethyltriphenylfosfonium bromide n-Butyltriphenylphosphonium bromide
CAS 1530-32-1 1779-51-7
EC 216-223-3 217-219-4
Common functional group 1 Triphenylphosphonium Triphenylphosphonium
Common functional group 2 counterion bromide counterion bromide
Deviating functional group alkyl chain ethyl alkyl chain butyl
Purity Please refer to section ´Confidential details in general comparable to source substance
on test material´ of the respective source substance ID.

3. ANALOGUE APPROACH JUSTIFICATION
The read-across hypothesis is based on the assumption that source and target do have comparable sensitising activity. Source and target are both alkyltriphenylphosphonium salts with an identical counterion, bromide. As n-Butyltriphenylphosphonium bromide differs from Ethyltriphenylfosfonium bromide only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl structures are not associated with a sensitising activity, this read-across is justified.
Reason / purpose for cross-reference:
read-across source
Key result
Parameter:
SI
Value:
1
Test group / Remarks:
1 and 2.5% source substance
Interpretation of results:
GHS criteria not met
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Read-across data used. The read-across hypothesis is based on the assumption that source and target do have comparable sensitising activity. Source and target are both alkyltriphenylphosphonium salts with an identical counterion, bromide. As n-Butyltriphenylphosphonium bromide differs from Ethyltriphenylfosfonium bromide only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl structures are not associated with a sensitising activity, this read-across is justified.

In an in vivo dermal sensitisation study (Local Lymph Node assay according toEU Method B.42 (2004),OECD guideline 429 (2002) andEPA OPPTS 870.2600(2003)), source substanceEthyltriphenylfosfonium bromide revealed no sensitising activity.Because of this result, n-Butyltriphenylphosphonium bromide in all probability has also no sensitising activity.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

In an in vivo dermal sensitisation study (Local Lymph Node assay) Ethyltriphenylfosfonium bromide revealed no sensitising activity.

As n-Butyltriphenylphosphonium bromide differs from Ethyltriphenylfosfonium bromide only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl structures are not associated with a sensitising activity, n-Butyltriphenylphosphonium bromide in all probability has also no sensitising activity.

According to the criteria of REGULATION (EC) No 1272/2008, n-Butyltriphenylphosphonium bromide does not have to be classified and has no obligatory labelling requirement for sensitization by skin contact.

According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2004), n-Butyltriphenylphosphonium bromide does not have to be classified for sensitization by skin contact.

n-Butyltriphenylphosphonium bromide is not classified for respiratory sensitisation because of lack of data.