Registration Dossier
Registration Dossier
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EC number: 701-171-0 | CAS number: -
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
One key study on ready biodegradability is available (BAZZON, 1997). The test substance (80% TSP and 20% DSP) was investigated in a "modified Sturm test" (CO2 evolution) according to the OECD Guideline No. 301 B (1992) and GLP. There was a deviation from the test guideline as the inoculum has been pre-adapted to the test substance. Therefore, this study is considered as reliable with restrictions.
In the test flasks, containing the test substance and activated sludge (inoculum) preadapted to the test item, no biodegradation was observed (based on amount of CO2 produced from test item, corrected for that derived from blank control and expressed as a percentage of the theoretical CO2) within the test period of 28 days. Therefore, the test substance (80% TSP and 20% DSP) was not readily biodegradable under the test conditions.
In the abiotic control, containing the test substance and poisoned mineral medium, no elimination was noted after 28 days of exposure (based on CO2 measurements). Thus, no abiotic elimination occurred under the test conditions.
In the inoculum control, the reference substance aniline was biodegraded at more than 70% in 14 days, thus confirming the suitability of the activated sludge.
In the toxicity control, containing the test substance, the reference substance aniline and activated sludge (inoculum), biodegradation amounted to 34% within 14 days of exposure. Thus, according to the test guidelines, the test substance was not inhibitory to activated sludge at the tested concentration of 20 mgOC/L because degradation was >25% within 14 days.
The biodegradation of individual constituents is further examined by way of the Catalogic QSAR. The model prediction indicates that TSP, 2,6-DSP and 2,4-DSP are not ready biodegradable.
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