Registration Dossier
Registration Dossier
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EC number: 701-171-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Very low acute toxicity by the oral or dermal route of administration
Key value for chemical safety assessment
Additional information
TSP/DSP was tested for its acute toxicity in Sprague-Dawley rats by the oral (RBM study No. 970071, 1997) and dermal routes (RBM study No. 970072, 1997). Both studies were key studies of validity 1 according to Klimisch criteria.
No mortality was observed up to the maximal doses tested, i.e. 40 g/kg bw for the oral route and 5 g/kg bw for the dermal route. Therefore no LD50 could be calculated for either route.
When applied dermally for 24 hours, the test substance induced no changes in appearance or behaviour, and no changes in body weight. When given orally at 10 g/kg and higher, signs of systemic toxicity (hypoactivity, piloerection, hunched posture, diarrhea and/or urine-stained perineum) were observed with dose-related onset and duration. Recovery was observed from day 8, except at 40 g/kg. Body weight was slightly and transiently affected at 20 g/kg and higher.
Overall, the acute toxicity of TSP/DSP appears very low, based on the results of the key studies provided.
Justification for classification or non-classification
Due to the absence of mortality at dose levels as high as 40 g/kg by the oral route and 5 g/kg by the dermal route, no classification is warranted for acute toxicity according to the criteria of Annex VI Directive 67/748/EEC or UN/EU GHS.
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