Biphenyl-2-ol, ethoxylated, esters with acrylic acid

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Qualifier:

according to guideline

Guideline:

OECD Guideline 211 (Daphnia magna Reproduction Test)

Deviations:

yes

Remarks:

Read-across to studies with other similar substances

Principles of method if other than guideline:

Read-across to 21-d studies on Daphnia magna for other substances with similar structures has been done. The toxic mode of action is identified to be the acrylate part of the substance.

GLP compliance:

yes

Remarks:

Assumed to be performed in accordance to GLP

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
not relevant

Details on sampling:

not relevant

Vehicle:

not specified

Details on test solutions:

not relevant

Test organisms (species):

Daphnia magna

Details on test organisms:

not relevant

Test type:

not specified

Water media type:

freshwater

Total exposure duration:

21 d

Post exposure observation period:

not relevant

Hardness:

not relevant

Test temperature:

not relevant

pH:

not relevant

Dissolved oxygen:

not relevant

Salinity:

not relevant

Nominal and measured concentrations:

not relevant

Details on test conditions:

not relevant

Reference substance (positive control):

not specified

Key result

Duration:

21 d

Dose descriptor:

EC10

Effect conc.:

ca. 0.1 mg/L

Nominal / measured:

not specified

Conc. based on:

dissolved

Basis for effect:

reproduction

Details on results:

Read-across

Results with reference substance (positive control):

Read-across study, i.e. no reference substance

Validity criteria fulfilled:

not applicable

Conclusions:

Based on read-across an EC10 (crustacean, 21 d) of 0.1 mg/L was derived.

Executive summary:

Read-across to 21-d studies on Daphnia magna of other substances with similar structures (OECD Guideline 211 (Daphnia magna Reproduction Test) has been done. These substances were: 2-phenoxyethyl acrylate (48145-04-6); methylacrylate (96-33-3), Ethylacrylate (140-88-5), butylacrylate (97-88-1), 2-hydroxyethyl acrylate (818-61-1)methacrylic acid, monoester with propane-1,2-diol (25584-83-2) and 2-phenoxyethanol (122-99-6).

The toxic mode of action was identified to be associated with the acrylate part of the substance. Based on this read-across, an EC10 of 0.1 mg/L was established.

Description of key information

21-day long-term EC10 values for the toxicity (reproduction) of  biphenyl-2 -ol, ethoxylated, esters with acrylic acid to the freshwater Daphnia magna was established on the basis of read-across to 7 other substances with a structure contained in phenoxyethyl acrylate. Test guideline followed for the 8 substances was OECD Guideline 211 (Daphnia magna Reproduction Test) or similar.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

0.1 mg/L

Additional information

21-day long-term EC10 values for the toxicity (reproduction) of phenoxyethylacrylate to the freshwater Daphnia magna was established on the basis of read-across to 7 other substances with a structure contained in phenoxyethyl acrylate (Methyl-acrylate, Ethyl acrylate, Butylacrylate, 2-ethylhexyl acrylate, Hydroxyethyl acrylate, Biphenyl, 2-phenoxyethanol). Test guideline followed for the 7 substances was OECD Guideline 211 (Daphnia magna Reproduction Test) or similar.