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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
Qualifier:
according to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Deviations:
yes
Remarks:
Read-across to studies with other similar substances
Principles of method if other than guideline:
Read-across to 21-d studies on Daphnia magna for other substances with similar structures has been done. The toxic mode of action is identified to be the acrylate part of the substance.
GLP compliance:
yes
Remarks:
Assumed to be performed in accordance to GLP
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
not relevant
Details on sampling:
not relevant
Vehicle:
not specified
Details on test solutions:
not relevant
Test organisms (species):
Daphnia magna
Details on test organisms:
not relevant
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
21 d
Post exposure observation period:
not relevant
Hardness:
not relevant
Test temperature:
not relevant
pH:
not relevant
Dissolved oxygen:
not relevant
Salinity:
not relevant
Nominal and measured concentrations:
not relevant
Details on test conditions:
not relevant
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
EC10
Effect conc.:
ca. 0.1 mg/L
Nominal / measured:
not specified
Conc. based on:
dissolved
Basis for effect:
reproduction
Details on results:
Read-across
Results with reference substance (positive control):
Read-across study, i.e. no reference substance
Validity criteria fulfilled:
not applicable
Conclusions:
Based on read-across an EC10 (crustacean, 21 d) of 0.1 mg/L was derived.
Executive summary:

Read-across to 21-d studies on Daphnia magna of other substances with similar structures (OECD Guideline 211 (Daphnia magna Reproduction Test) has been done. These substances were: 2-phenoxyethyl acrylate (48145-04-6); methylacrylate (96-33-3), Ethylacrylate (140-88-5), butylacrylate (97-88-1), 2-hydroxyethyl acrylate (818-61-1)methacrylic acid, monoester with propane-1,2-diol (25584-83-2) and 2-phenoxyethanol (122-99-6).

The toxic mode of action was identified to be associated with the acrylate part of the substance. Based on this read-across, an EC10 of 0.1 mg/L was established.

Description of key information

21-day long-term EC10 values for the toxicity (reproduction) of  biphenyl-2 -ol, ethoxylated, esters with acrylic acid to the freshwater Daphnia magna was established on the basis of read-across to 7 other substances with a structure contained in phenoxyethyl acrylate. Test guideline followed for the 8 substances was OECD Guideline 211 (Daphnia magna Reproduction Test) or similar.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.1 mg/L

Additional information

21-day long-term EC10 values for the toxicity (reproduction) of phenoxyethylacrylate to the freshwater Daphnia magna was established on the basis of read-across to 7 other substances with a structure contained in phenoxyethyl acrylate (Methyl-acrylate, Ethyl acrylate, Butylacrylate, 2-ethylhexyl acrylate, Hydroxyethyl acrylate, Biphenyl, 2-phenoxyethanol). Test guideline followed for the 7 substances was OECD Guideline 211 (Daphnia magna Reproduction Test) or similar.