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EC number: 212-634-7 | CAS number: 834-12-8
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The 48-hour contact LD50 for worker honey bees (Apis mellifera) was determined to be greater than 100 µg/bee. The no-observed-effect dosage was 100 µg/bee.
Key value for chemical safety assessment
Additional information
Toxicity to terrestrial arthropods.001 - honeybees - 1988 – key: Acute contact toxicity to worker honey bees (Apis mellifera) was assessed according to the methods defined by the US Environmental Protection Agency Office of Pesticide Programs (EPA OPP) 141-1 (Honey Bee Acute Contact Toxicity) according to GLP. The study exposed 25 bees per dose in duplicate to the test substance by application on the thorax and/or abdomen using a micro-applicator, followed by an observation period of 2 days. Temperature was maintained at 21-23ºC with a relative humidity of 65% and the bees were kept in the dark except during dosing and during daily observations. Observations were made for mortality and signs of toxicity twice on the day of initiation and once on Day 1 and Day 2 after dosing. The 48-hour contact LD50 was determined to be greater than 100 µg/bee. The no-observed-effect dosage was 100 µg/bee.
Toxicity to terrestrial arthropods.002 - honeybees – 1995: Acute contact toxicity to worker honey bees (Apis mellifera) was assessed according to the methods defined by the Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renovaveis - IBAMA, under the Toxic Substance Control Act N 139 not according to GLP. The study exposed 20 bees per dose in duplicate to the test substance by application on the thorax using a micro-applicator, followed by an observation period of 1 day. The 24-hour contact LD50 was determined to be greater than 20 µg/bee. The no-observed-effect dosage was 20 µg/bee.
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