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EC number: 257-573-7 | CAS number: 51981-21-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
See below
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The acute oral, dermal and inhalation toxicity of the read across substance GLDA-Na4 is low with the LD50 values being higher than 2000 mg/kg bw and the 4 -h LC50 value being higher than 4.2 mg/L (technically highest attainable concentration). The repeated dose toxicity studies (90 -day, developmental and 2 -generation study) also revealed that GLDA-Na4 has a low toxicity. Therefore, an extensive toxicokinetic assessment is considered of limited value. Below an assessment of the anticipated toxicokinetic behaviour of GLDA-Na4/GLDA-H4 is given.
The water solubility of GLDA is very high (>60% wt) and therefore in principle not considered a rate limiting factor for the absorption of the compound from the gastro-intestinal tract. However, the size of the molecules is quite large. Urine samples collected in rats at the end of a 90 -day oral gavage study, showed levels of 2 and 1.3% of the nominal intake in males and females, respectively. An absorption study (single gavage dose of 1000 mg/kg bw) in rats revealed an absorption up to 5%.
Therefore, also based on data on other chelates like EDTA-H4 and EDTA-Na4, for organic, soluble GLDA-Na4 the intestinal absorption was estimated to be 5%. Since it is generally accepted that substances with log Pow ranging from 0.1 to 6 penetrate the skin easily, and the log Pow of GLDA-Na4 was measured to be <0 and calculated to be -11.95, it is expected that GLDA-Na4 will be hardly absorbed through the skin. Comparing again to EDTA-H4 and EDTA-Na4, skin absorption was estimated to be 0.001%. Based on the particle size distribution of GLDA-Na4, it is expected that at least 90% of the inhaled substance will be deposited in the upper respiratory tract, which will finally be taken up orally. Of this, only 5% will be absorbed in the gastrointestinal tract and become available systematically, i.e. 0.9 x 0.05 = 0.045 (4.5%). The other maximally 10% may reach the alveoli and it is assumed that this will be absorbed completely (worst case). Therefore, the total inhalation absorption factor will be 0.045 + 0.10 = 0.145 (14.5%). It is not expected that the GLDA moiety undergoes biotransformation. Evidence for this conclusion comes from the oral absorption study in rats that showed almost 100% recovery in urine and feces and from studies with EDTA-FeNa which indicated that both EDTA and iron are excreted unchanged following ingestion of NaFeEDTA. Because of the high water solubility, the fraction of unchanged compound that would be absorbed will be readily excreted via the kidneys (i.e. at relatively high doses of 300 -1000 mg/kg bw slight kidney toxicity was seen).
Based on the rat absorption study, it was indeed found that when a limited amount of GLDA-Na4 is being absorbed, on average >85% is rapidly (first 24 hours) excreted via urine/faeces by the animal. Based on the expected kinetic behaviour in the body as described above, it is expected that GLDA-Na4 will not extensively be absorbed from the gastro-intestinal tract but when absorbed it will be readily excreted. Therefore, accumulation in the body during prolonged exposure is not anticipated.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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