Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics, other
Remarks:
toxicokinetic assessent based on physico-chemical data
Type of information:
other: toxicokinetic assessent based on physico-chemical data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: toxicokinetic assessent based on physico-chemical data

Data source

Reference
Reference Type:
other: toxicokinetic assessent based on physico-chemical data
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Objective of study:
absorption
distribution
excretion
metabolism
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
toxicokinetic assessent based on physico-chemical data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
421-140-2
EC Name:
-
Molecular formula:
C12H22O4Mg
IUPAC Name:
Magnesium bis(2-ethylbutanoate)
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Magnesium bis (2-ethylbutanoate)
- Substance type: White powder with crystals
- Physical state: Solid



Specific details on test material used for the study:
no actual material used, assessment performed with general available data

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
see section "any other information on results incl. tables"
Type:
distribution
Results:
see section "any other information on results incl. tables"
Type:
metabolism
Results:
see section "any other information on results incl. tables"
Type:
excretion
Results:
see section "any other information on results incl. tables"

Any other information on results incl. tables

Based on above data the substance may not be absorbed through the skin in relevant amounts as the Log POWis below the lower threshold of -1 (molecular weight < 500 g/Mol, -1 < log POW< 4, see EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRETORATE-GENERAL: Guidance Document on Dermal Absorpiton Sanco/222/2000 rev. 7 19 March 2004).

For exposure assessments a default value of 10 % of absorption after dermal exposure may be appropriate.

The uptake after direct inhalation of the solid substance may be of significant relevance due to the portion of Substance having inhalable diameter (< 100 µm). For Risk assessment purposes a value of 100 % absorption after inhalation may be appropriate. Uptake by inhalation after evaporation is unlikely, the substance is a solid at room temperature having a high melting point together with a very low vapour pressure.

The absorption after oral ingestion cannot be calculated due to lack of data; by default an absorption of 100 % may be appropriate, until specific data will be available, although such a high absorption is rather unlikely.

 

 


Distribution:

The substance is highly hydrophilic, therefore distribution to lipophilic body tissues is unlikely. The limited stability together with the high hydrophilicity likely excludes bio accumulation. There is no further information available therefore a more detailed description is futile.

Upon dissolution of the substance in water, the ionic substance will dissociate into (hydrated) Magnesium ions and 2-Ethylbutanoate. The later is a week acid and in aqueous solution an equilibria between the negative charged 2-Ethylbutanoate and the neutral 2-Ethylbutyric acid will establish.

2-Ethylbutyric acid and Mg ions are water soluble, too, therefore the dissociation event does not alter the previous conclusion drawn.

 

 

Metabolism and Excretion:

Taking into account the structural elements of the formula it follows that the unchanged substance and the conjugated organic acid are possible substrates for Phase II Enzymes.

There is no indication whether a Glutathion-, Sulphate-, Acetate- or Glucuronate adduct is favoured.

 

The high water solubility of the substance indicates urinary excretion as the most relevant way of excretion for the unchanged substance.

Another relevant pathway for exretion may be by feces, especially for the fraction, which has not been absorbed in the gastrointestinal tract after oral uptake.

Excretion by exhalation does not seem to be relevant.

Applicant's summary and conclusion

Conclusions:
toxicokinetic assessent based on physico-chemical data performed