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EC number: 213-944-5 | CAS number: 1068-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Skin: The test substance was not irritating to the rabbits' skin under the test conditions chosen.
Eye: The test substance was not irritation to the rabbits' eye under the test conditions chosen.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: the test compound was received from Lucidol Division, Wallace and Tiernan, Inc.
- Weight at study initiation: 1729 to 2504 g
- Housing: All animals were placed in holders designed to immobilize the animal - Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved and abraded
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied:0.5 mL/rabbit - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- twelve albino rabbits (two groups of 6 animals)
- Details on study design:
- TEST SITE
- Area of exposure: Approximately one inch square on each site of the back of the animals.
- Type of wrap if used: The rabbits were further prepared following application by placing a piece of rubber dam 2x2 inches over each area of application. The damming was held in place with adhesive tape and the entire trunk of each animal wrapped with rubberized cloth bandage to hold the patches in place and retard the evaporation of volatile substance.
REMOVAL OF TEST SUBSTANCE
- Washing: The back of each rabbit was washed with lukewarm water
- Time after start of exposure: 24 hours
READINGS: The areas of compound application were exermined after 24 hours and 72 hours - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- On the basis of the results obtained in this study, the test substance does not possess any primary irritating properties to the skin of albino rabbits under the test conditions chosen.
- Executive summary:
The test substance was applied once only at a total volume of 0.5 mL/rabbit to the prepared dermal surface of the back of albino rabbits. On the basis of the results obtained in this study, the test substance dies not possess any primary irritating properties to the skin of this species under the test conditions chosen (mean erythema score and mean edema score = 0).
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- All housing and care were based on the standars recommended by the Guide for the Care and Use of Laboratory Animals.
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Adult, New Zealand White rabbits were received at SLI from Myrtle's Rabbitry, Thompson Station, TN.
- Animal Selection: The animals for study were arbitrarily selected from healthy stock animals to avoid potential bias. All animals received a detailed pretest observation prior to dosing. Only healthy animals were chosen for study use. Females were nulliparous and nonpregnant.
- Housing: The animals were housed individually in suspended stainless steel cages.
- Identification: Plastic ear tags displaying unique identification numbers were used to individually identify the animals.
- Diet: PMI Certified Rabbit Chow #5322 (Purina Mills, Inc.) was provided ad libitum to the animals throughout the study.
- Water: Municipal tap water treated by reverse osmosis was available ad libitum throughout the study. the purified water was supplied by an automatic watering system.
- Acclimation period: Animals were acclimated for a minimum of five days to the laboratory conditions. The animals were observed daily for overt physical or behavioral abnormalities, general health/moribundity and mortality.
ENVIRONMENTAL CONDITIONS
- Temperature: ca. 16.7 - 18.9 °C
- Humidity: 52 - 64 %:
- Air changes: 10 - 15 per hour
- Photoperiod: 12-hour light/12-hour dark - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the other eye, remaining untreated, serves as a control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL
- Concentration: 100 % - Duration of treatment / exposure:
- single treatment
- Observation period (in vivo):
- 1, 24, 48 and 72 hours after dosing
- Number of animals or in vitro replicates:
- 6 (2 males, 4 females)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: At the 24 hour scoring interval, any residual test acticle was gently rinsed from the eye at this time using physiological saline. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this test, the test substance is considered to be a non irritant to the ocular tissue of the rabbit.
- Executive summary:
In this study, the potential irritant and/or corrosive effects of the test substance were evaluated on the eyes of New Zealand White rabbits. Each of six rabbits received a 0.1 mL dose of the test article in the conjunctival sac of the right eye. The contralateral eye of each animal remained untreated and served as a control. Test and control eyes were examined for signs of irritation for up to 72 hours following dosing. Exposure of the test article produced conjunctivitis (redness and/or swelling and/or discharge) in 6/6 test eyes at the 1 hour scoring interval. The conjunctival irritation resolved completely in all animals by the 72 hour scoring interval. A mean conjunctivae score (24,48,72h) of 0.4 was determined. The observed mean scores for cornea, iris and chemosis were 0. Under the conditions of this test, the test substance is considered to be a non irritant to the ocular tissue of the rabbit.
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation study:
In a skin irritation study, the test substance was applied once only at a total volume of 0.5 mL/rabbit to the prepared dermal surface of the back of albino rabbits (International Research & Development Corporation 1964). On the basis of the results obtained in this study, the test substance dies not possess any primary irritating properties to the skin of this species under the test conditions chosen (mean erythema score and mean edema score = 0).
Eye irritation study:
In a eye irritation study, the potential irritant and/or corrosive effects of the test substance were evaluated on the eyes of New Zealand White rabbits (Springborn Laboratories 1996, 3255.103). Each of six rabbits received a 0.1 mL dose of the test article in the conjunctival sac of the right eye. The contralateral eye of each animal remained untreated and served as a control. Test and control eyes were examined for signs of irritation for up to 72 hours following dosing. Exposure of the test article produced conjunctivitis (redness and/or swelling and/or discharge) in 6/6 test eyes at the 1 hour scoring interval. The conjunctival irritation resolved completely in all animals by the 72 hour scoring interval. A mean conjunctivae score (24,48,72h) of 0.4 was determined. The observed mean scores for cornea, iris and chemosis were 0. Under the conditions of this test, the test substance is considered to be a non irritant to the ocular tissue of the rabbit.
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008 (CLP). As a result the substance is not considered to be classified for skin and eye irritation under Regulation (EC) No 1272/2008, as amended for the fifteenth time in Regulation (EU) 2020/1182.
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