Registration Dossier
Registration Dossier
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EC number: 203-898-4 | CAS number: 111-71-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Heptanal
- EC Number:
- 203-898-4
- EC Name:
- Heptanal
- Cas Number:
- 111-71-7
- Molecular formula:
- C7H14O
- IUPAC Name:
- heptanal
- Details on test material:
- - Name of test material (as cited in study report): 74-12
- Substance type: C7 aldehyde
- Physical state: no data
- Analytical purity: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Storage condition of test material: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing:no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum):no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- no data
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10 animals were used (no data on sex)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: no data - Statistics:
- No statistics were performed.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No death was observed during the course of the study.
- Clinical signs:
- other: None
- Gross pathology:
- no data
- Other findings:
- skin irritation:
Moderate redness - 8/10
Marked redness - 2/10
Moderate edema - 7/10
Marked edema - 3/10
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and CLP classification
- Conclusions:
- Under the conditions of this test, the test compound did not induced any mortality among the animals at the tested dose level of 5000 mg/kg.
- Executive summary:
In an acute dermal toxicity study, 10 rats were given a single dermal dose of heptanal at a dose level of 5000 mg/kg bw and observed for 14 days. No death occured during the course of the study. No clinical signs were reported. LD0 = 5000 mg /kg bw in rats.
Under the conditions of this test, heptanal is therefore not classified according to EU and GHS classifications.
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