Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 March 2017- 11 April 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
May 31, 2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling Point)
Version / remarks:
Juy 27, 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
Version / remarks:
August 1996
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-methyl-prop-2-enamide
EC Number:
611-915-5
Cas Number:
59941-98-9
Molecular formula:
C16 H18 N4 O3 S
IUPAC Name:
N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-methyl-prop-2-enamide
Test material form:
solid: particulate/powder
Remarks:
white crystalline

Results and discussion

Boiling point
Key result
Decomposition:
yes
Remarks:
Reaction and/or decomposition of the test item was observed during DSC experiments during and after melting.
Remarks on result:
not determinable
Remarks:
Reaction and/or decomposition of the test item was observed during DSC experiments during and after melting. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no boiling temperature.

Any other information on results incl. tables

Preliminary Test

Starting at 315°C, the weight of the sample decreased significantly. At 342°C, the sample weight had decreased by 25%.

After the experiment, a black molten residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item.

Main Study

An endothermic peak was observed between 200°C and 250°C. The extrapolated onset temperature of the peak was 237.431°C. The endothermic effect was most likely obtained due to melting of the test item. An exothermic peak was observed between 275°C and 342°C. The exothermic effect was due to reaction and/or decomposition of the test item.

After the experiment, a brown/black molten residue remained in the sample container.

In order to investigate the melting peak, Experiment 2 was stopped directly after the melting peak. The extrapolated onset temperature was 237.051°C. After the experiment, a light yellow molten residue remained in the sample container (original colour: white) container. Based on this visual observation, it was found that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.

The melting temperature was determined as the mean melting temperature of Experiment 1 (237.431°C) and Experiment 2 (237.051°C)

Applicant's summary and conclusion

Conclusions:
The melting and boiling temperature of V123109 were determined by DSC.
The melting temperature of the test item was 237.2°C (510.4K). The estimated accuracy, according to the OECD Guideline 102 , for this method is ± 0.5°C.
Reaction and/or decomposition of the test item was observed during DSC experiments during and after melting. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no boiling temperature.