1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate

Endpoint summary

Description of key information

Short-term aquatic toxicity data are available for each of the three freshwater trophic levels (fish, daphnia and algae). Experimental studies are available for daphnia (EC50 = 0.9 mg/L) and for algal inhibition (ErC50 > 3.17 mg/L, NOEC = 1.83 mg/L). In the absence of experimental data, the acute toxicity to fish has been assessed using a QSAR approach. The QSAR approach works within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible. Three predictions were performed giving estimated 96h LC50 values of 0.628 mg/L, 0.759 mg/L and 1.5 mg/L. The models used are independent from each other (e.g. based on different training sets) and thus the agreement among the predictions increases the confidence in the reliability of the predictions.

Toxicity to microorganisms was assessed as part of a standardised ready biodegradation test. The substance did not inhibit degradation of the positive control at a test concentration of 100mg/L. Thus this concentration can be considered the NOEC for toxicity to STP microorganisms.