Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Annex VII of Regulation (EC) No 1907/2006 in section 8.3 relating to skin sensitisation states :-

The assessment of this endpoint shall comprise the following consecutive steps:

(1) an assessment of the available human, animal and alternative data,

(2) In vivo testing.

Furthermore Step 2 does not need to be conducted if the available information indicates that the substance should be classified for skin sensitisation or corrosivity.

The SIDS dossier does not identify any skin sensitisation studies relating to 2,4-dichlorophenol and notes that may not be achievable with a corrosive substance. Two observations are noted in that chloracnea has been reported during exposure to a mixture of chlorophenols which included 2,4-dichlorophenol. These observations were derived from two surveys, performed in 1964 ( Bleiberg J .et al [1964], Arch.Dermatol., 89: 793-797) and 1971 ( Poland A.P. et al. [1971] Arch. Environ. Health, 22: 316-327 ), on workers in a chemical factory engaged in the manufacture of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichloro-phenoxyacetic acid. These surveys revealed a large incidence of chloracnea cases among the workers (Bleiberg J., 1964), (Poland A.P., 1971).

The substance is classified as corrosive. Therefore, no additional considerations are required as regards skin sensitisation.


Migrated from Short description of key information:
The substance is classified as corrosive. Therefore, the performance of a skin sensitisation study may not be achievable and should not be considered appropriate as regards animal protection.
Therefore, no additional considerations are required as regards skin sensistisation.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Not classified for respiratory sensitisation. The substance is corrosive.


Migrated from Short description of key information:
Substance is classified as corrosive

Justification for classification or non-classification