Registration Dossier
Registration Dossier
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EC number: 204-429-6 | CAS number: 120-83-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Annex VII of Regulation (EC) No 1907/2006 in section 8.3 relating to skin sensitisation states :-
The assessment of this endpoint shall comprise the following consecutive steps:
(1) an assessment of the available human, animal and alternative data,
(2) In vivo testing.
Furthermore Step 2 does not need to be conducted if the available information indicates that the substance should be classified for skin sensitisation or corrosivity.
The SIDS dossier does not identify any skin sensitisation studies relating to 2,4-dichlorophenol and notes that may not be achievable with a corrosive substance. Two observations are noted in that chloracnea has been reported during exposure to a mixture of chlorophenols which included 2,4-dichlorophenol. These observations were derived from two surveys, performed in 1964 ( Bleiberg J .et al [1964], Arch.Dermatol., 89: 793-797) and 1971 ( Poland A.P. et al. [1971] Arch. Environ. Health, 22: 316-327 ), on workers in a chemical factory engaged in the manufacture of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichloro-phenoxyacetic acid. These surveys revealed a large incidence of chloracnea cases among the workers (Bleiberg J., 1964), (Poland A.P., 1971).
The substance is classified as corrosive. Therefore, no additional considerations are required as regards skin sensitisation.
Migrated from Short description of key information:
The substance is classified as corrosive. Therefore, the performance of a skin sensitisation study may not be achievable and should not be considered appropriate as regards animal protection.
Therefore, no additional considerations are required as regards skin sensistisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Not classified for respiratory sensitisation. The substance is corrosive.
Migrated from Short description of key information:
Substance is classified as corrosive
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
