Registration Dossier
Registration Dossier
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EC number: 235-436-2 | CAS number: 12227-50-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 13 Sep - 22 Oct 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal Register
- Version / remarks:
- 1973
- GLP compliance:
- no
Test material
- Reference substance name:
- 4',4'''-azobis[N-(9,10-dihydro-9,10-dioxo-1-anthryl)[1,1'-biphenyl]-4-carboxamide]
- EC Number:
- 235-436-2
- EC Name:
- 4',4'''-azobis[N-(9,10-dihydro-9,10-dioxo-1-anthryl)[1,1'-biphenyl]-4-carboxamide]
- Cas Number:
- 12227-50-8
- Molecular formula:
- C54H32N4O6
- IUPAC Name:
- 4',4'''-azobis[N-(9,10-dihydro-9,10-dioxo-1-anthryl)[1,1'-biphenyl]-4-carboxamide]
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Remarks:
- SPF-Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight: 1.5 - 2.0 kg
- Housing: single cages
- Diet (e.g. ad libitum): ad lib.
- Water (e.g. ad libitum): ad lib.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm²
- Type of wrap if used: PVC foil, elastic wrap
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: removal after 24 h
OBSERVATION TIME POINTS
24, 48, 72 h
SCORING SYSTEM:
- Method of calculation: Draize scoring
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.06
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance did not cause any significant signs of irritation. Slight edema in 1/6 animals was fully reversible within 48 h. Therefore, the substance is not classifiable according to CLP criteria.
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