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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2000-09-14 to 2000-12-27
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
4-trans-Propyl-4-trans-(3,4,5-trifluorphenyl)-[1,1-bicyclohexyl]
EC Number:
603-522-2
Cas Number:
131819-23-3
Molecular formula:
C21H29F3
IUPAC Name:
4-trans-Propyl-4-trans-(3,4,5-trifluorphenyl)-[1,1-bicyclohexyl]
Test material form:
solid
Specific details on test material used for the study:
Batch: E998833

Sampling and analysis

Analytical monitoring:
yes
Details on sampling:
0; 24; 48; 72; 96 h

Test solutions

Vehicle:
yes
Details on test solutions:
Test solution 1: 2 mg/L test material + 10 mg/L HCO-40
Control solution: 10 mg/L HCO-40

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
Weight: 0.2 g
Length: 2 cm
Lot: 00-H0310
delivery: 10 Mar 2000

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
no

Test conditions

Test temperature:
22.5-23.7 °C
pH:
According to guideline
Dissolved oxygen:
According to guideline
Salinity:
According to guideline
Nominal and measured concentrations:
nominal 2 mg/L
Details on test conditions:
10 fish per 4 L
Reference substance (positive control):
not specified

Results and discussion

Effect concentrations
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
- Mortality of control:
10 mg HCO-40 / L: 0% (24h), 0% (48h), 0% (72h), 0 %(96 h)

- Mortality of test group:
2 mg test material / L + 10 mg HCO-40 / L: 0% (24h), 0% (48h), 0% (72h), 0 %(96 h)

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The LC50 of the test material with solubilizer exceeds 2 mg/L, which is clearly above the limit of water solubility.
Executive summary:

The informtion for this endpoint study record was obtained from an experimental study. The OECD GLP criteria were met and the methods applied are fully compliant with OECD TG 203. The LC50 of the test material with solubilizer exceeds 2 mg/L, which is clearly above the limit of water solubility.