Registration Dossier
Registration Dossier
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EC number: 203-767-1 | CAS number: 110-43-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In general, absorption of alcohol and secondary aliphatic ketones is expected to occur rapidly in the tract gastrointestinal.
The possible metabolic reactions involved in the biotransformation of secondary ketones are:
(i) ketone reduction to the corresponding secondary alcohol, with subsequent excretion in the urine or in the bile as conjugate of the acid glucuronide;
(ii) omega oxidation of short-chain ketones (carbon atoms <5) or group oxidation terminal methyl and subsequent oxidation to produce an alpha-keto-carboxylic acid;
(iii) oxidation of doubles ties.
A
rabbit study showed that about 41% of 2-Eptanone given orally is
eliminated with urine in the form of conjugated glucuronic acid
(heptil-2-glucuronide). More
recent studies have shown that 2-Heptanone can be transformed into
hydroxyketone, subsequently transformed into heptane-2,6-dione via
oxidation.
Key value for chemical safety assessment
Additional information
Bibliographic source:
WHO (World Health Organization), 2000. Evaluation of certain food additives. Fifty-first meeting of the Joint
FAO/WHO Expert Committee on Food Additives. Geneva, 9–18 June 1998. WHO Technical Report Series, No 891.
WHO, Geneva, Switzerland
EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed), 2015. Scientific
opinion on the safety and efficacy of saturated and unsaturated aliphatic secondary alcohols, ketones and esters with
esters containing secondary alcohols belonging chemical group 5 when used as flavourings for all animal species.
EFSA Journal 2015;13(11):4268, 21 pp. doi:10.2903/j.efsa.2015.4268
GESTIS Substance Database. Heptane-2-one
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