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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritive database

Data source

Reference
Reference Type:
publication
Title:
Hazardous Substances Data Bank (HSDB) for linalol
Author:
U.S National Library of Medicine
Year:
2017
Bibliographic source:
Hazardous Substances Data Bank (HSDB) for linalool U.S National Library of Medicine 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate eye irritation potential of (3S)-3,7-dimethylocta-1,6-dien-3-ol on New Zealand white rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Linalool
EC Number:
201-134-4
EC Name:
Linalool
Cas Number:
78-70-6
Molecular formula:
C10H18O
IUPAC Name:
(3S)-3,7-dimethylocta-1,6-dien-3-ol
Test material form:
liquid
Details on test material:
IUPAC name:(3S)-3,7-dimethylocta-1,6-dien-3-ol
commen name: Linalool
Molecular formula :C10H18O
Molecular weight: 154.251 g/mol
substance type: organic
Physical state: liquid
InChI:1S/C10H18O/c1-5-10(4,11)8-6-7-9(2)3/h5,7,11H,1,6,8H2,2-4H3
Smiles:C([C@@](C=C)(C)O)C\C=C(\C)C
Specific details on test material used for the study:
IUPAC name: (3S)-3,7-dimethylocta-1,6-dien-3-ol
commen name: Linalool
Molecular formula :C10H18O
Molecular weight: 154.251 g/mol
substance type: organic
Physical state: liquid
InChI:1S/C10H18O/c1-5-10(4,11)8-6-7-9(2)3/h5,7,11H,1,6,8H2,2-4H3
Smiles:C([C@@](C=C)(C)O)C\C=C(\C)C

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Amount-01ml
Concentration-100%, 30%,10%
Duration of treatment / exposure:
Not specified
Observation period (in vivo):
Not specified
Number of animals or in vitro replicates:
Total=6
Details on study design:
Not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: Not specified
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Irritation was moderate at 100%, slightly at 30%; very slightly at 10%

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
(3S)-3,7-dimethylocta-1,6-dien-3-ol when subjected to 6 New Zealand white rabbits in concentration 100%, 30% and 10% produced positive ocular irritation effects . Hence, (3S)-3,7-dimethylocta-1,6-dien-3-ol was considered to be eye irritant.
Executive summary:

(3S)-3,7-dimethylocta-1,6-dien-3-ol was used as test material to evaluate its eye irritation potential on 6 New Zealand white rabbits.

The test material was subjected to the conjunctive sac of rabbit in the concentration 0.1 ml (100%, 30% and 10%).

Irritation was moderate at 100%, slightly at 30%; very slightly at 10%. As all the above concentrations produced positive ocular irritation reactions. Hence, (3S)-3,7-dimethylocta-1,6-dien-3-ol was considered to be eye irritant.

 

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