Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts

Endpoint summary

Description of key information

The test material is not acute toxic. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

3 600 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Dose descriptor:

LC50

Value:

2 000 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

13 800 mg/kg bw

Additional information

This substance does not show any evidence of toxicity via the oral route of exposure in animals when tested in accordance with OECD Guideline 401. The rat oral LD50 is 3,600 mg/kg in male rats. Sublethal effects of lethargy, piloerection, diarrhea, ptosis, chromodacryorrhea, and dyspnea were observed in all groups. Necropsy observations included gastrointestinal abnormalities; no specific organ toxicity is significant; all animals showed expected bodyweight gain during the study course. 

 

This substance does not show adverse toxicity effects via the dermal route of exposure in animals when tested in accordance with OECD Guideline 402. The rat dermal LD50 is greater than 13800 mg/kg in male rabbits. Toxic signs observed in all dose groups included mucus in feces, yellow nasal discharge, alopecia, lethargy, ptosis, no specific organ toxicity is evident.

 

This substance does not show evidence of systemic toxicity, or specific organ toxicity, via the inhalation route of exposure in animals when tested in accordance with OECD Guideline 403. After one hour whole body exposure, clinical signs included lethargy, piloerection, chromorhinorrhea, tachypnea, ptosis, and body weight loss; no mortality occurred; no specific organ toxicity is evident.

Justification for classification or non-classification

In accordance to Directive 67/548/EEC and EU CLP (Regulation (EC) No. 1272/2008), classification of this substance is not required for acute toxicity.