Registration Dossier
Registration Dossier
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EC number: 272-723-1 | CAS number: 68909-93-3
Endpoint summary
Administrative data
Description of key information
The test material is not acute toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 600 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 2 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 13 800 mg/kg bw
Additional information
This substance does not show any evidence of toxicity via the oral route of exposure in animals when tested in accordance with OECD Guideline 401. The rat oral LD50 is 3,600 mg/kg in male rats. Sublethal effects of lethargy, piloerection, diarrhea, ptosis, chromodacryorrhea, and dyspnea were observed in all groups. Necropsy observations included gastrointestinal abnormalities; no specific organ toxicity is significant; all animals showed expected bodyweight gain during the study course.
This substance does not show adverse toxicity effects via the dermal route of exposure in animals when tested in accordance with OECD Guideline 402. The rat dermal LD50 is greater than 13800 mg/kg in male rabbits. Toxic signs observed in all dose groups included mucus in feces, yellow nasal discharge, alopecia, lethargy, ptosis, no specific organ toxicity is evident.
This substance does not show evidence of systemic toxicity, or specific organ toxicity, via the inhalation route of exposure in animals when tested in accordance with OECD Guideline 403. After one hour whole body exposure, clinical signs included lethargy, piloerection, chromorhinorrhea, tachypnea, ptosis, and body weight loss; no mortality occurred; no specific organ toxicity is evident.
Justification for classification or non-classification
In accordance to Directive 67/548/EEC and EU CLP (Regulation (EC) No. 1272/2008), classification of this substance is not required for acute toxicity.
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