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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Repeat dose oral toxicity data is not available for EC 272-723-1, but an OECD 422 study is available for an analogous substance and suitable for read across. 

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
160 mg/kg bw/day
Study duration:

Additional information

The oral repeat dose toxicity of an analog substance was evaluated with rats at doses as high as 160 mg/kg/day for up to 52 consecutive days in accordance with OECD 422. Substance-related toxicity was limited to morbundity, adverse clinical signs, and epithelial hyperplasia, hyperkeratosis, and inflammation of the stomach. The NOAEL for systemic toxicity was 160 mg/kg/day. The NOEL for portal of entry irritation and related secondary effects parental toxicity was 40 mg/kg/day. 


Justification for classification or non-classification

In accordance to Directive 67/548/EEC and the EU CLP (Regulation (EC) No. 1272/2008) classification of this substance is not required for prolonged exposure.