Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 294-461-7 | CAS number: 91722-61-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Juniperus mexicana, Cupressaceae.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Test was conducted according to methods similar to OECD guideline 401 (limit test) and was performed pre-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Juniper, Juniperus mexicana, ext.
- EC Number:
- 294-461-7
- EC Name:
- Juniper, Juniperus mexicana, ext.
- Cas Number:
- 91722-61-1
- Molecular formula:
- Not available since an UVBC substance.
- IUPAC Name:
- Essential oil of Cedarwood Texas obtained from the wood of Juniperus mexicana (Cupressaceae) by distillation
- Test material form:
- liquid
- Details on test material:
- CAS 91722-61-1
For specific details on test material if available - See in RSS
Name of test material (as cited in study report or in reference): Cedarwood Texas oil
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch No.of test material: EOA 75-12
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: none
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not Specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Not Specified, sex not specified
- Doses:
- one limit dose of 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Daily
- Necropsy of survivors performed: yes
- Other examinations performed: symptomatology
Results and discussion
- Preliminary study:
- Not relevant
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was noted
- Clinical signs:
- other: No effects observed
- Gross pathology:
- No effects mentioned
- Other findings:
- Not other effects were reported.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- based on CLP Regulation (1272/2008/EC).
- Conclusions:
- The oral LD50 value of Cedarwood Texas oilin rats was established as exceeding 5000 mg/kg body weight, under the conditions of this study. The substance therefore does not need to be classified in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
A single 5000 mg/kg bw dose of Cedarwood Texas oil was administered by oral gavage to 10 rats. The animals were observed for 14 days. No symptoms or mortality were noted. The oral LD50 value of
Cedarwood Texas oil in rats was established as exceeding 5000 mg/kg body weight, under the conditions of this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
