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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from review articles

Data source

Reference
Reference Type:
review article or handbook
Title:
701. Diphenylamine (Pesticide residues in food: 1984 evaluations)
Author:
FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues
Year:
1984
Bibliographic source:
Diphenylamine- PESTICIDE RESIDUES IN FOOD – 1984, Sponsored jointly by FAO and WHO

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of Diphenylamine in guinea pigs
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Diphenylamine
EC Number:
204-539-4
EC Name:
Diphenylamine
Cas Number:
122-39-4
Molecular formula:
C12H11N
IUPAC Name:
Diphenylamine
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): Diphenylamine
- Molecular formula: C12H11N
- Molecular weight: 169.226 g/mol
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Diphenylamine
- Molecular formula: C12H11N
- Molecular weight: 169.226 g/mol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5g
Duration of treatment / exposure:
no data available
Observation period:
no data available
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritant / corrosive response data:
Slight irritation was observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Slight irritation was observed when diphenylamine was applied to the skin of rabbits.
Hence, diphenylamine can be considered to be slightly irritating to skin.
Executive summary:

The dermal irritation potential of Diphenylamine was assessed in rabbits. Undiluted 0.5 g of diphenylamine was applied to the intact and abraded skin of rabbits and observed for signs of irritation (duration of application and observation period not mentioned).

Slight irritation was observed when diphenylamine was applied to the skin of rabbits.

Hence, diphenylamine can be considered to be slightly irritating to skin.