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Administrative data

Endpoint:
surface tension
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 February 2013 - 28 March 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study has been performed in accordance with the EC A.5 and OECD 115 guidelines and complied with the principles of GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.5 (Surface Tension)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 115 (Surface Tension of Aqueous Solutions)
Version / remarks:
(1995)
Deviations:
no
GLP compliance:
yes
Type of method:
OECD harmonised ring method

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminopyrazine-2-carboxylic acid
EC Number:
226-558-7
EC Name:
3-aminopyrazine-2-carboxylic acid
Cas Number:
5424-01-1
Molecular formula:
C5H5N3O2
IUPAC Name:
3-aminopyrazine-2-carboxylic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Amiloride Compound 5
- Description: Tan powder
- Storage condition of test material: In refrigerator (2-8°C) protected from light, desiccated
- Other: Reactive to light, moisture and oxygen

Results and discussion

Surface tension
Surface tension:
73.6 mN/m
Temp.:
20 °C
Conc.:
1 g/L

Any other information on results incl. tables

Surface tension measurements

 

Measurement

 

Time passed [minutes]

Surface tension

[mN/m]

individual

Mean (1)

mean corrected (2)

1

23

73.2

72.9

73.6

2

24

72.4

3

25

73.0

4

26

72.9

5

28

72.8

6

29

72.9

7

30

72.9

(1) Mean calculated from measurements 3 to 7

(2) Multiplied by the calibration factor followed by correction according to Harkins-Jordan

Applicant's summary and conclusion

Conclusions:
The surface tension of an aqueous solution of the substance at 1 g/L was determined to be 73.6 mN/m at 20°C using the OECD Harmonized ring method (GLP-compliant study in accordance with EC A.5 and OECD 115). Because this is not < 60 mN/m, Amiloride Compound 5 is not surface active according to the EC A.5 guideline.