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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 February 2013 - 28 March 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study has been performed in accordance with the EC A.4 and OECD 104 guidelines and complied with the principles of GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
(2009)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
(2006)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
(1996)
Deviations:
no
GLP compliance:
yes
Type of method:
other: Effusion method: Isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminopyrazine-2-carboxylic acid
EC Number:
226-558-7
EC Name:
3-aminopyrazine-2-carboxylic acid
Cas Number:
5424-01-1
Molecular formula:
C5H5N3O2
IUPAC Name:
3-aminopyrazine-2-carboxylic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Amiloride Compound 5
- Description: Tan powder
- Storage condition of test material: In refrigerator (2-8°C) protected from light, desiccated
- Other: Reactive to light, moisture and oxygen

Results and discussion

Vapour pressureopen allclose all
Temp.:
25 °C
Vapour pressure:
6.4 other: E-04 Pa
Temp.:
20 °C
Vapour pressure:
3 other: E-04 Pa

Any other information on results incl. tables

Results of the isothermal TGA analysis

 

Temperature

[°C]

Weight loss

[µg/min]

νT

[g/cm2/h]

logνT

logPT

110

6.922

8.26 E-04

-3.08

1.07

5.049

6.03 E-04

-3.22

0.93

120

14.74

1.76 E-03

-2.75

1.42

12.91

1.54 E-03

-2.81

1.36

130

31.15

3.72 E-03

-2.43

1.76

28.85

3.44 E-03

-2.46

1.73

140

63.01

7.52 E-03

-2.12

2.08

59.98

7.16 E-03

-2.15

2.06

 

Vapour pressure regression curve: log PT = -5646x1/T + 15.74 (r = 0.994, n = 8).

Log PT 20°C was calculated to be -3.52

Log PT 25°C was calculated to be -3.19

 

Applicant's summary and conclusion

Conclusions:
The vapour pressure of Amiloride Compound 5 was determined to be 6.4E-04 Pa at 25°C (3.0E-04 Pa at 20°C) using the isothermal thermogravimetric effusion method (GLP-compliant study in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950).