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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Environmental fate & pathways

Henry's Law constant

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Description of key information

Key value for chemical safety assessment

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The Henry's Law constant of HFE-7500 was determined by the ratio of measured gas-phase concentration over aqueous-phase concentration.


Duplicate test vessels at three headspace:water ratios (70%, 50% and 30%) were incubated at ambient temperature (~23°C) for 4, 5, 6, 7 and 8 days, corresponding to time point 1, 2, 3, 4 and 5. After incubation, duplicate aliquot of the headspace and water phase were removed from each test system vial and transferred to separate vials for analysis. The measured gas phase and water phase concentrations from each aliquots were averaged and used to calculate Henry's Law constant for HFE-7500 for each test vessel. The overall average HLC for HFE-7500 is 19100 (%RSD = 21, n=22). The dimensionless HLC can be converted to 4.7E+07 Pa·m³/mol or 464 atm·m³/mole. This study was conducted under GLP compliance with accepted method. However, there were several samples that had high %RPD. Therefore, it is considered reliable with restrictions and considered as a key study.


Two HLC values were reported based on measured vapor pressure over water solubility. These values are no longer considered.

The photodegradation products of CAS# 297730-93-9, HF, TFA, and PFBA, are highly water soluble and deprotonate readily at environmental pH. They are not expected to be volatile in aquatic systems.