Registration Dossier

Administrative data

Description of key information

Acute oral toxicity is greater than 2000 mg/kg bw in rats when tested according to EU Method B.1.
Acute dermal toxicity is greater than 2000 mg/kg bw in rats when tested according to OECD method 402.
Key Value for Safety Assessment;
Oral
Effect Level: LD50 greater than 2000 mg/kg
Dermal
LD50: Greater than 2000 mg/kg bw

Key value for chemical safety assessment

Additional information

Acute Oral Toxicity: 3 animals were dosed by oral gavage at 2000 mg/kg bw. No vehicle was used. No animals died, no clinical signs were observed and the animals gained weight as expected. The LD50 oral is reported as greater than 2000 mg/kg bw.

 

Acute Dermal Toxicity: 5 males and 5 females were administered a dose of 2000 mg/kg bw for 24 hours under an occlusive dressing. No animals died, no clinical signs were observed and the animals gained weight as expected. The LD50 dermal is greater than 2000 mg/kg bw.

Justification for classification or non-classification