Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 247-063-2 | CAS number: 25513-64-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
2,2,4 (or 2,4,4)-trimethylhexane-1,6-diamine might fulfil the criterion for persistence, but not the criteria for bioaccumulation and toxicity detailed in Annex XIII. Since only one criterion of the PBT and vPvB criteria is fulfilled, the substance can not be considered a PBT or vPvB.
Screening tests on biodegradation in water showed that the substance is neither readily nor inherently degradable.
Based on the information available at the moment, the substance has to be classified as persistent and very persistent respectively.
The log Kow of 2,2,4 (or 2,4,4)-trimethylhexane-1,6-diamine was determined experimentally according to OECD guideline No. 117. The value of -0.3 at 25 °C and pH 7.5 is well below the criterion of 4.5.
The criteria for toxicity according to Annex XIII are chronic toxicity data for the aquatic environment. If these values are below 0.01 mg/l the substance can be regarded as potentially toxic. The lowest valid chronic test result derived from aquatic toxicity testing with fish, invertebrates and algae are as follows:
Daphnia magna (21d): NOEC = 1.02 mg/L
Since the lowest chronic test data are well above 0.01 mg/l, the criterion for toxicity is not fulfilled.
Furthermore the substance is not classified as T, R48, or Xn, R48 according to Directive 67/548/EEC and is not carcinogenic, mutagenic or toxic for reproduction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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