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According to a Mackay Level I model calculation, the main target compartment for 2,2,4(2,4,4)-trimethylhexane-1,6-diamine will be the hydrosphere (99.97 %), followed the atmosphere 0.02 %). The calculated Henry’s law constant of 0.00063 Pa m3/mol indicates very low volatility of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine from surface waters. The adsorption coefficient of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine corrected for dissociation was calculated with a QSAR published by Franco and Trapp (2008). The result was Koc = 25, log Koc = 1.40 (pH 7), corresponding to a very low potential for geoaccumulation (Blume scale).