Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine (CAS-No. 25513-64-8); Information/Assumptions regarding toxicokinetics

The following remarks on the toxicokinetics of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine

are based on physiochemical properties of the compound and on toxicological data. Experimental toxicokinetic studies were not performed.

2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine is a colourless liquid with a low vapour pressure (0.04 hPa at 20 °C, Degussa AG, 2002) under normal ambient conditions.

The substance is classified as corrosive. Hence 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine is also considered to be corrosive or irritant to the respiratory tract if inhaled. Therefore, no acute or repeated dose toxicity studies are available for the inhalative route of exposure. It is expected that all clinical signs and histopathological findings occured in those studies would be related to the corrosive /irritant properties of the substance.

Oral absorption of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine could not be excluded based on an LD50(rat) of 910 mg/kg bw and a NOAEL (rat) of 10 mg/kg bw/day derived from a 90 -day study. In these studies, increase in kidney weights (acute toxicity study) and significantly higher (than controls) mean liver weights (repeated dose toxicity study) were observed.

Furthermore, the test substance has shown skin sensitizing properties in a guinea pig maximization test (Hüls AG, 1984), thus indicating that a dermal uptake, even though small, can occur.

No data are available regarding the excretion of absorbed .2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine.

Because of the very low partition coefficient n-octanol/water (log Kow = -0.3 at 25 °C and pH 7.5; AQura, 2010) a significant accumulation of2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine in organism is not expected.