Registration Dossier
Registration Dossier
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EC number: 247-063-2 | CAS number: 25513-64-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- Preliminary LD50 for dose selection
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,4(or 2,4,4)-trimethylhexamethylenediamine
- IUPAC Name:
- 2,2,4(or 2,4,4)-trimethylhexamethylenediamine
- Test material form:
- other: liquid
- Details on test material:
- 2,2,4(or 2,4,4)-trimethylhexamethylenediamine of Hüls AG, purity not reported.
Constituent 1
Test animals
- Species:
- hamster, Chinese
- Strain:
- other: Han-Chinese
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Age: 3 to 4 months
- Source: Zentralinstitut für Versuchskunde, Hanover (Germany)
- No. of animals per dose: 1 male + 1 female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- ADMINISTRATION:
- Vehicle: water (aqua ad injectabilia); 10 ml/kg bw applied
- Post dose observation period: not reported - Doses:
- 30; 60; 125; 250 mg/kg bw
- No. of animals per sex per dose:
- 1
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 125 mg/kg bw
- Mortality:
- MORTALITY:
250 mg/kg bw: 2/2 animals died within 3 hours.
125 mg/kg bw: The male died within 24 hours. - Clinical signs:
- CLINICAL SIGNS:
250 mg/kg bw: Severe apathia, sedation, hypothermia, loss of general reactions, reduced righting reflexes, temporarily Writhing reflexes as a
sign of abdominal pain reactions, irregular respiration (dyspnea).
125 mg/kg bw: Similar signs but less severe, recovery of surviving animal
60 mg/kg bw: Slight apathia (transient)
30 mg/kg bw: No signs
Applicant's summary and conclusion
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