Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
1 025 mg/kg bw
Quality of whole database:
Study conducted according to internationally accepted testing guidelines.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The solid substance was assessed according to OECD GD 129 (3T3 NRU). Preliminary value of LD50= 1025 mg/kg is confirmed with comparison of similar substances, suggesting a classification for the test item of our interest.

Justification for classification or non-classification

Adopting the WoE approach based on the result of OECD GD 129 on the test item of our interest ( IC50  about 450 μg/ml i.e. LD50= 1025 mg/kg) and considering the data regarding acute oral toxicity available for similar substances, the substance is classified H302 “Harmful if swallowed”” according to the CLP regulation (EC n.1272/2008).