Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-464-5 | CAS number: 72207-77-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April / May 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- AcidBrown311
- IUPAC Name:
- AcidBrown311
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 100 - 118 g
- Fasting period before study: the rats were starved overnight before treatment with test item
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: the substance was prepared as a 30% aqueous suspension
- Amount of vehicle: dosage volume of 16.7 ml/kg bodyweight. - Doses:
- 5000 mg/kg b.w
- No. of animals per sex per dose:
- 10 males per dose
- Control animals:
- yes
- Remarks:
- rats treated with water alone (16.7 ml/kg)
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: all rats were examined macroscopically in an attempt to identify any target organs.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no mortalities
- Clinical signs:
- other: Slight to moderate lethargy, pilo-erection, diarrhoea and solivation
- Gross pathology:
- No finding
- Other findings:
- Recovery of the treated rats, as judged by external appearance and behaviour, was apparently complete two days after the treatment.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- The LD50 to male rats was found to be greater than 5000 mg/kg bodyweight.
- Executive summary:
The substance was tested for acute toxicity by oral route administration. Five male rats were tested at concentration of 5000 mg/kg b.w and other five male were used as vehicle control. No mortalities was registered. The LD50 to male rats was found to be greater than 5000 mg/kg bodyweight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
