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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

The substance is acutely toxic to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
4.57 mg/L

Additional information

In the key study (NITE Japan, 2002; NMMP/E00/2090), the acute toxicity of 2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine) (CAS 6864 -37 -5) was analyzed in a static test according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). The test item concentrations were analytically verified to be stable regarding sufficient recovery (> 80%).The 48-h EC50 was determined to be 4.57 mg/L (result based on not pH-adjusted test solutions).

In a supporting study (BASF AG, 1988; 1/0330/2/88-0330/88) according to EU Method C.2, Directive 79/831/EEC, Annex V, Part C, the 48-EC50 was determined to be 15.2 mg/L. Analytical monitoring of the test solutions was not conducted in this study.

In conclusion, the test substance is considered to be acutely toxic to aquatic invertebrates.