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Ecotoxicological information

Toxicity to birds

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In Annex X, section 9.6.1 of the Regulation (EC) No 1907/2006 REACH concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), it is suggested, that in case of long term toxicity testing to birds "any need for testing should be carefully considered taking into account the large mammalian dataset that is usually available at this tonnage level." Furthermore, ECHA (2008) states in the "Guidance on information requirements and chemical safety assessment Chapter R.7c" (R.7.10.6) that "given that mammalian toxicity is considered in detail for human health protection, the need for additional data for birds must be considered very carefully – new tests are a last resort in the data collection process." In addition, based on the low log Kow and the low measured and estimated BCF values, significant bioaccumulation in organisms is not to be expected (see IUCLID Ch. 5.3.1).  Hence, secondary poisoning is of no concern. Taking this into account, long-term or reproductive toxicity tests on birds do not need to be conducted due to the facts that a mammalian dataset is available.