Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable calculation.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR calculation
Title:
Unnamed
Year:
2014
Report Date:
2014

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR calculation using SkinPerm v1.03
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 3,3'-Dimethyl-4,4'-diaminodicyclohexylmethane
- pure substance

Results and discussion

Percutaneous absorption
Remarks on result:
other: maximal absorption: 0.00257 mg/cm2/h

Applicant's summary and conclusion

Conclusions:
A maximal dermal absorption of 0.00257 mg/cm2/h was determined. This value was used to estimate the internal exposure of DMDC after each application (process category) as shown in chapter 9 & 10 of the CSR.