Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption, other
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable calculation.

Data source

Reference
Reference Type:
other: QSAR calculation
Title:
Unnamed
Year:
2014
Report date:
2014

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR calculation using SkinPerm v1.03
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine)
EC Number:
229-962-1
EC Name:
2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine)
Cas Number:
6864-37-5
Molecular formula:
C15H30N2
IUPAC Name:
4-[(4-amino-3-methylcyclohexyl)methyl]-2-methylcyclohexan-1-amine

Results and discussion

Percutaneous absorption
Remarks on result:
other: maximal absorption: 0.00257 mg/cm2/h

Applicant's summary and conclusion